Two Papers From: DiabetesPro SmartBrief
Gestational diabetes linked with persistent metabolic changes
Women with a history of gestational diabetes were more likely to have hyperglycemia and insulin resistance five years after giving birth than those without a history of GDM, according to a 63-patient study in theInternational Journal of Endocrinology. Reduced levels of adiponectin and higher concentrations of C-reactive protein were also seen in women with prior GDM.Healio (free registration)/Endocrine Today(4/3)
Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45?pGDM with NGT were compared to 18 women without a history of GDM (CON), matched for age (37.0??4.1 versus 35.2??5.3, ) and BMI (24.3??3.1 versus 23.3??3.3, ). Metabolic parameters were derived from oral and intravenous glucose tolerance tests; furthermore lipid profile, C-reactive protein (CRP), adiponectin, leptin, and glucagon were assessed. Results. Five years postpartum, pGDM had increased glucose concentrations during the OGTT (AUC: 1.12??0.15 versus 1.0??0.12?mol/L min, ) and insulin sensitivity was decreased compared to CON (OGIS: 467.2??64.1 versus 510.6??53.1?mL/min m2, ). pGDM had lower adiponectin (8.1??2.6 versus 12.6??5.3, ) but increased waist circumference and CRP compared to CON. Conclusions. Despite diagnosis of normal glucose tolerance, pGDM are characterized by hyperglycemia and insulin resistance compared to healthy controls, accompanied by decreased adiponectin and increased CRP concentrations, thus linking metabolic disturbances to an increased cardiovascular risk in pGDM.
Exposure to maternal diabetes lowers GLP-1 levels in adults
Adult offspring of mothers who had gestational diabetes or type 1 diabetes during pregnancy showed lower levels of fasting glucagon-like peptide 1 and weakened glucagon suppression than those who were not exposed to maternal diabetes, according to a study published inThe Journal of Clinical Endocrinology & Metabolism.Healio (free registration)/Endocrine Today
Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons but further investigations are needed.